The Sims 4 All Ailments: How to Cure Every Disease (March 2026)

Your Sims can contract various ailments, illnesses, and magical afflictions throughout their virtual lives in The Sims 4. From fairy-induced magical maladies to deadly rodent diseases, these conditions can range from mildly inconvenient to potentially fatal. I’ve compiled this comprehensive guide covering every single ailment across all expansions, including the new Enchanted by Nature pack, with detailed symptoms and cure methods to keep your Sims healthy and thriving.

The Sims 4: All Ailments at a Glance

Ailment Type	Expansion Pack	Severity	Fatal?	Cure Method
Fairy Ailments (8 types)	Enchanted by Nature	Moderate	No	Elixirs, Naturopath, Fairy cure
Get to Work Illnesses (8 types)	Get to Work	Mild	No	Medicine, tea, rest
Jungle Poison	Jungle Adventure	Severe	Yes	Antidote (computer/locals)
Rabid Rodent Fever	My First Pet Stuff	Severe	Yes	Rodent serum
Werebies	Werewolves	Moderate	No*	Bartender remedy
Food Poisoning	Dine Out	Mild	No	Wait it out

*Werebies transforms Sims into werewolves if untreated

The Sims 4: All Ailments

Ailments in The Sims 4 are special conditions that affect your Sims’ mood, behavior, and sometimes their survival. Unlike regular illnesses that appeared in Get to Work, the newer ailments from Enchanted by Nature and other packs often have unique visual effects, contagious properties, and sometimes even beneficial side effects. Understanding how to identify, prevent, and cure these conditions is crucial for maintaining your Sims’ wellbeing and preventing unexpected deaths.

Enchanted by Nature Ailments: Magical Maladies

The Enchanted by Nature expansion introduces eight unique ailments that occur when Sims become emotionally imbalanced or cross paths with mischievous fairies. These magical conditions aren’t always negative – some players strategically use certain ailments for their beneficial effects!

1. Burning Passion Ailment

Symptoms:

• Constant Flirty moodlet
• May spontaneously set objects on fire
• Visible flames or heat waves around the Sim

Cure: Heartbreak Elixir (Level 1 Apothecary) Ingredients: Valerian root + Carrot

2. Whirling Wonder Ailment

Symptoms:

• Dizziness and disorientation
• Spinning animation
• Difficulty completing tasks

Cure: Steadying Serum (Level 2 Apothecary) Ingredients: Sage + Mushroom

3. Gnome Infestation Ailment

Symptoms:

• Gnomes mysteriously appear around the lot
• Gnomes may break appliances
• Uncomfortable moodlets

Cure: Gnome-Be-Gone Tonic (Level 2 Apothecary) Ingredients: Basil + Apple

4. Sprouting Seedlings Ailment

Symptoms:

• Plants growing from the Sim’s body
• Green patches on skin
• Increased gardening skill gain

Cure: Weed Killer Elixir (Level 1 Apothecary) Ingredients: Parsley + Strawberry

5. Melodic Madness Ailment

Symptoms:

• Uncontrollable singing
• Musical notes floating around
• May disturb other Sims

Cure: Silence Syrup (Level 2 Apothecary) Ingredients: Chamomile + Blueberry

6. Glowing Aura Ailment

Symptoms:

• Bright glow surrounding the Sim
• Attracts insects at night
• May blind other Sims temporarily

Cure: Dimming Draught (Level 1 Apothecary) Ingredients: Lavender + Blackberry

7. Frozen Features Ailment

Symptoms:

• Icy appearance
• Slowed movement
• Frost forming on nearby objects

Cure: Thawing Tincture (Level 2 Apothecary) Ingredients: Cinnamon + Orange

8. Bubble Trouble Ailment

Symptoms:

• Bubbles constantly emanating from Sim
• Slippery floors
• Hygiene decreases faster

Cure: Pop Prevention Potion (Level 1 Apothecary) Ingredients: Mint + Grape

How to Cure Enchanted by Nature Ailments

There are five main methods to cure fairy ailments:

1. Craft Elixirs at the Apothecary Table ($100 from Build/Buy)
   • Level up your Apothecary skill by crafting
   • Purchase ingredients or forage them in Innisgreen
   • Each ailment has a specific cure recipe
2. Call a Naturopath ($1,500 Simoleons)
   • Use your phone to schedule a house call
   • The Naturopath will diagnose and cure your ailment
   • Most expensive but guaranteed method
3. Ask a Fairy for Help
   • Any fairy can cure ailments (except their own)
   • Free but requires befriending a fairy
   • Find fairies in the Everdew neighborhood
4. Visit Moondrop Springs
   • Located in Everdew neighborhood
   • Select “Manifest an Ailment Cure”
   • Free but requires traveling to Innisgreen
5. Wait It Out
   • Ailments naturally expire after 3-5 days
   • Some players keep beneficial ailments active
   • No cost but prolonged discomfort

For faster skill progression, check out our guide on Sims 4 skill cheats to max out your Apothecary skill instantly!

Get to Work Illnesses: Medical Conditions

The Get to Work expansion introduced eight illnesses that Sims can catch randomly, especially during cold and flu season if you have Seasons installed.

Bloaty Head

Symptoms: Headache aura, steam from ears, holding head Treatment: Immunization shot or medicine from computer

Burnin’ Belly

Symptoms: Stomach rubbing, fever, pink medicine thought bubble Treatment: Surgery at hospital or medicine

Gas & Giggles

Symptoms: Tiger stripe rash, uncontrollable laughter, flatulence Treatment: Medicine from computer or pharmacy

Itchy Plumbob

Symptoms: Stripe rash, constant scratching, discomfort Treatment: Surgery or medicine

Llama Flu

Symptoms: Dot rash, coughing, sneezing, fever Treatment: Immunization shot or rest

Starry Eyes

Symptoms: Dizziness, swatting at air, swirl rash, stars around head Treatment: Medicine or tea

Sweaty Shivers

Symptoms: Multiple rashes, fever, itching, shivering Treatment: Immunization shot

Triple Threat

Symptoms: All three rash types, severe multiple symptoms Treatment: Surgery (most serious illness)

How to Cure Get to Work Illnesses

1. Purchase Medicine (Fastest method)
   • Click on computer → Order → Purchase Medicine ($50)
   • Take medicine from inventory
   • Instant cure with 4-hour Energized moodlet
2. Natural Remedies
   • Drink orange juice (from fridge quick meals)
   • Brew any tea using Tea Magic Personal Brewer
   • Reduces illness duration but not instant
3. Rest and Sleep
   • Click on bed → Nap or Sleep
   • Shortens illness duration
   • Free but time-consuming

If you’re playing as a doctor, check out our best laptops for Sims 4 guide to ensure smooth gameplay during hospital shifts!

Jungle Adventure: Deadly Poison

Jungle Adventure introduces the most dangerous ailment in the game – poison that can actually kill your Sim within 72 hours if left untreated.

Causes of Poisoning

• Spider bites in the jungle
• Bee stings while exploring
• Poison darts in temples
• Walking through poison gas traps
• Contact with poisoned ghosts

Poison Progression

1. Initial Bite/Exposure: “Feeling Slightly Strange” (12 hours)
2. Stage 1: “Feeling Icky” – Green splotches appear (8 hours)
3. Stage 2: “Really Very Ill” – Increased discomfort (8 hours)
4. Stage 3: “Seriously Ill” – Severe symptoms (16 hours)
5. Stage 4: “Overwhelmingly Poisoned” – Final warning (8 hours)
6. Death: Sim dies if not cured

How to Cure Jungle Poison

1. Computer Antidote ($1,000)
   • Use any computer → Order → Buy Antidote
   • Most reliable method
   • Works instantly
2. Ask Locals with Bone Dust
   • Must have Ancient Bone Dust in inventory
   • Talk to Selvadoradian locals (not tourists)
   • Select “Ask About Antidote” under Friendly
   • Trade bone dust for cure
3. Marketplace Cures
   • Purchase preventive items from vendors:
   • Spider Repellent (prevents bites)
   • Plasma Bat Bait (repels bats)
   • Fire Foam (for temple traps)
4. Statue Offering ($250)
   • Visit Madre Cosecha statue in marketplace
   • Select “Donate to Dispel Curse”
   • Grants skeleton blessing after cure

For easier exploration, use move objects cheats to place protective items strategically in the jungle!

My First Pet Stuff: Rabid Rodent Fever

This pack brings back the infamous guinea pig disease from The Sims 1, now called Rabid Rodent Fever – a contagious and potentially fatal illness.

Disease Progression

1. Bite-Sized Bite (2 hours) – Tense moodlet after being bitten
2. Fuzzy Feeling (24 hours) – Uncomfortable, disease takes hold
3. Fuzzy Fever (24 hours) – Highly contagious stage
4. Rabid Rodent Fever (24 hours) – Final stage before death
5. Death – Sim dies and returns as hamster ghost

How to Contract the Disease

• Dirty rodent cage + poor relationship with pet
• Bite from infected rodent
• Contact with contagious Sim
• Only affects teens and older

Prevention and Cure Methods

1. Research and Purchase Remedies
   • Use computer → Web → Research Rabid Rodent Fever
   • Unlocks purchase options:
   • Rabid Rodent Serum ($500) – Cures active disease
   • Rabies Inoculation Serum ($800) – Permanent immunity
2. Vet Clinic Help (Cats & Dogs required)
   • Ask employees about Rabid Rodent Fever
   • Purchase remedies at clinic computer
   • Professional consultation available
3. Prevention Tips
   • Keep rodent cages clean
   • Maintain good relationships with pets
   • Inoculate Sims preemptively
   • Isolate infected Sims

Note: Ghost Sims who died from this disease appear as oversized hamsters and can drink inoculation serum to return to normal ghost form!

Werewolves: Werebies Infection

The Werewolves pack introduces Werebies – a transformative disease that turns Sims into werewolves if not cured quickly.

How to Contract Werebies

• Greg attacks in underground tunnels
• Werewolf bites during rampages
• Exploring dangerous areas in Moonwood Mill
• Fighting with werewolves

Symptoms

• Angry moodlet: “Feeling irate after that brush with werewolves”
• Foaming at the mouth
• Visible bite marks
• Transformation begins within 36 hours

Cure Methods (Must Act Fast!)

1. Grimtooth Bar Remedy
   • Click on bartender (not bar)
   • Select “Ask for Werebies Remedy”
   • Drink mysterious beverage immediately
   • Free and most reliable
2. Home Remedies (May require multiple attempts)
   • Toilet: “Try to Force Werebies Out”
   • Shower: “Try to Cleanse Self of Werebies”
   • Treadmill: “Try to Run Werebies Off”
3. Information Panel
   • Visit Moonwood Mill Info Panel
   • Select “View Werebies Advisory”
   • Provides cure instructions

If transformation occurs, check out our CAS cheat guide to customize your new werewolf form!

Other Notable Illnesses

Food Poisoning (Dine Out)

• Cause: Eating at low-quality restaurants
• Symptoms: Nausea, vomiting
• Cure: Wait it out, report to restaurant for compensation

Morning Sickness (Base Game)

• Cause: Pregnancy
• Symptoms: Nausea in first trimester
• Cure: Time or pregnancy termination

Vampire Weaknesses (Vampires)

• Withered Stomach: Nausea from normal food
• Sun Exposure: Burns and discomfort
• Cure: Blood consumption or vampire cure

Pro Tips for Managing Ailments

1. Stock Medicine Cabinet
   • Keep ailment cures in inventory
   • Pre-purchase antidotes before traveling
   • Maintain high Apothecary skill
2. Prevention Strategies
   • Emotional balance prevents fairy ailments
   • Clean environments reduce disease risk
   • Good relationships prevent bites
3. Strategic Ailment Use
   • Some ailments boost skills
   • Burning Passion helps romance
   • Sprouting Seedlings aids gardening
4. Emergency Preparedness
   • Know nearest cure locations
   • Keep Simoleons for expensive cures
   • Multiple cure methods for backup
5. Mod Compatibility
   • Some mods affect ailment mechanics
   • Check mod compatibility guides
   • Update mods after patches

Ailment-Specific Careers and Skills

Naturopath Career (Enchanted by Nature)

• Treat clients from home
• Diagnose ailments professionally
• Earn money curing others
• Unlock special interactions

Doctor Career (Get to Work)

• Hospital-based illness treatment
• Diagnose using visual symptoms
• Perform surgeries for severe cases
• Career progression through cures

Apothecary Skill Benefits

• Level 1-2: Basic ailment cures
• Level 6: Emotion stones
• Level 9: No negative smell debuffs
• Level 10: Advanced ingredients, potion conversion

Expansion Pack Interactions

Different expansion packs can affect how ailments work:

• Seasons: Increases illness frequency in winter
• Eco Lifestyle: Green footprint areas have fewer illnesses
• Cottage Living: Animals can spread some diseases
• Island Living: Mermaids immune to certain ailments
• Realm of Magic: Spellcasters can cure some conditions

Death and Ghost Mechanics

Fatal ailments create unique ghost types:

• Poison Death: Green gaseous ghost
• Rabid Rodent Fever: Hamster-suited ghost
• Emotional Extremes: Color-coded ghosts

Ghosts retain some ailment properties and may need special cures to normalize their appearance.

Troubleshooting Common Issues

Cure Not Working?

• Ensure correct diagnosis
• Check if ailment has multiple stages
• Some conditions need specific timing
• Verify no mod conflicts

Can’t Find Cure Ingredients?

• Visit Desert Bloom Park for foraging
• Purchase from Apothecary table
• Check grocery stalls
• Use debug cheats if desperate

Ailment Won’t Go Away?

• Some last 3-5 days naturally
• Multiple cure attempts may be needed
• Check for reinfection sources
• Reset Sim with cheats if glitched

Conclusion

Managing ailments in The Sims 4 adds depth and challenge to your gameplay, whether you’re dealing with magical fairy afflictions, medical emergencies, or transformative diseases. By understanding each condition’s symptoms and cures, you can keep your Sims healthy or strategically use ailments to your advantage. Remember that preparation is key – stock up on cures, maintain good relationships, and always have a backup plan for those unexpected poisonous encounters in the jungle!

With this comprehensive guide, you’re now equipped to handle any ailment The Sims 4 throws at your Sims. From the whimsical troubles of fairy magic to the deadly dangers of jungle exploration, you’ll never be caught off-guard by mysterious symptoms again. Happy Simming, and may your medicine cabinets always be well-stocked!